Clinical Trials

As part of the University of California, the center has access to leading-edge research that makes it possible to apply new approaches to diabetes treatment. From time to time, there are opportunities for patients and community members to participate in studies and trials. Check this site often or sign up for our newsletter to stay informed about the latest advances in diabetes treatment and management.

The Effect of Diet Beverages on Diabetes Control: A Pilot Study

Condition/Disease: Diabetes
Lead Researcher: Andrew Odegaard, PhD, MPH
Location: UC Irvine Main Campus & UC Irvine Medical Center

Purpose: The purpose of this research study is to test an important question in relation to dietary recommendations for men and women with type 2 diabetes. Do diet beverages (e.g. diet Coke or diet Pepsi) influence aspects of diabetes control?


  • Man or a woman with type 2 diabetes clinically diagnosed ≥ one year ago
  • Age of diagnosis 35-75 years
  • HbA1c 6.5-9.0% (average blood glucose measure over previous two to three months)
  • Only on therapy that does not include low blood sugar episodes (hypoglycemia) as a side effect with stability for the prior three months
  • Willing to drink diet beverages daily during a one month period and avoid them the other one month period
  • Not actively looking to lose weight, or alter diet or lifestyle (e.g. physical activity pattern) during the study participation
  • English speaking

Time Commitment: Six hours over two and a half to three months.

Benefits: N/A

Compensation: $40

UC Irvine Department of Epidemiology
Phone: 949-824-8544

Purine therapy for newly-diagnosed type-1 diabetes mellitus

Condition/Disease: Diabetes
Lead Researcher: Alan Elias, MD
Location: UC Irvine Medical Center, 101 The City Blvd South, Orange, CA 92868

Purpose: To investigate the ability of a naturally occurring food substance in retarding or preventing the progression of Type-1 diabetes.

Eligibility: Males and females, age 6 years of age or older with Type-1 diabetes mellitus, diagnosed within the past 6 months.

Time Commitment: The study will be conducted over a one to two year period. Participants will receive monthly medical evaluations. Blood sampling related to the study will be performed four times over a two year period.

Benefits: There is no guarantee of any benefit from participating in this study, but the information obtained may aid in the development of better treatments in retarding or preventing the progression of Type-1 diabetes.

Compensation: Study drug, office visits, research blood tests, exams, training or any procedure required by this study will be provided at no cost.

Ramona Rodriguez, MD, Department of Endocrinology
Phone: 714-456-5125

For more information or to find other UC Irvine Health Clinical Trials visit: